Trifluoroacetic acid → HCID 68813278, compound

HRID 2105951Notes

Reaction equation

HRID 2105951 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1([OH:25])[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:1][C:2]1[C:7]([C:8]([F:10])([F:11])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1([OH:25])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57438794HCID 57438794, compound

Product 1

HCID 68813278HCID 68813278, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to Preparation 2: Tert-butyl 4-[2-fluoro-3-(trifluoro-methyl)phenyl]-4-hydroxypiperi-dine-1-carboxylate (3.1 g, 8.5 mmol, methylen chloride (20 ml), trifluoroacetic acid (2 ml). Yield: 0.62 g. MS m/z (rel. intensity, 70 eV) 263 (M+, 22), 245 (96), 244 (44), 191 (25), 56 (bp).

Workup

  1. customAccording to Preparation 2

Sources & evidence

ORD record
ord-6acb7c39a7a74a31a6a2426c432a2719
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

Loading…