反应详情

To a suspension of lithium aluminum hydride (0.75 g) in THF (20 mL) stirred under nitrogen was added dropwise a solution of methyl 3-methyl-3-(2-methoxy-5-fluorophenyl)butanoate (4.2 g) dissolved in THF (10 mL). The mixture was stirred at room temperature for 4 hours. The reaction was quenched by cautious addition of water (1 mL) and diluted with ether (100 mL). The mixture was filtered through FLORISIL® selective adsorbent and evaporated to dryness in vacuo to give 3-methyl-3-(2-methoxy-5-fluorophenyl)butan-1-ol as an oil (3.30 g, 89%).

1. stirringThe mixture was stirred at room temperature for 4 hours
2. customThe reaction was quenched by cautious addition of water (1 mL)
3. additiondiluted with ether (100 mL)
4. filtrationThe mixture was filtered through FLORISIL® selective adsorbent
5. customevaporated to dryness in vacuo