2-Ethylphenol → HCID 68815364, compound

HRID 2106432Notes

Reaction equation

HRID 2106432 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]([CH2:17][CH3:18])(O)[CH2:14][CH3:15])=[CH:10][C:9]=2[CH:19]=1)=[O:4].[CH2:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[OH:28])[CH3:21].B(F)(F)F.CC[O:35][CH2:36][CH3:37]>>[CH3:3][C:5]([CH3:6])([CH3:19])[C:36](=[O:35])[CH2:37][O:28][C:23]1[CH:24]=[CH:25][C:26]([CH:14]([CH:13]([C:11]2[O:12][C:8]3[CH:7]=[CH:6][C:5]([C:3]([OH:2])=[O:4])=[CH:19][C:9]=3[CH:10]=2)[CH2:17][CH3:18])[CH3:15])=[CH:27][C:22]=1[CH2:20][CH3:21]

Participants

4

Reactant 3

HCID 69972-EthylphenolHCID 8000Boron trifluoride etherateHCID 57810594HCID 57810594, compound

Product 1

HCID 68815364HCID 68815364, compoundYield 149.9%

Procedure

2-(1-Ethyl-1-hydroxy-propyl)-benzofuran-5-carboxylic acid methyl ester (1.01 g, 3.85 mmol) and 2-ethylphenol (0.706 g, 5.77 mmol) and BF3-Et2O (273 mg, 1.925 mmol) are reacted analogous to step D to give the title compound (1.30 g, 92%).

Sources & evidence

ORD record
ord-2df5e867aa894d2dbabb5f0c65bc0670
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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