Potassium Carbonate → HCID 68815347, compound

HRID 2106433Notes

Reaction equation

HRID 2106433 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]([CH2:25][CH3:26])(C3C=CC(O)=C(CC)C=3)[CH2:14][CH3:15])=[CH:10][C:9]=2[CH:27]=1)=[O:4].Br[CH2:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32].[C:36]([O-:39])([O-])=O.[K+].[K+]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([CH:13]([CH:25]([C:5]3[CH:6]=[CH:7][C:36]([O:39][CH2:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32])=[C:9]([CH2:10][CH3:11])[CH:27]=3)[CH3:26])[CH2:14][CH3:15])=[CH:10][C:9]=2[CH:27]=1)=[O:4]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 57810557HCID 57810557, compound

Product 1

HCID 68815347HCID 68815347, compoundYield 198.9%

Procedure

2-[1-Ethyl-1-(4-hydroxy-3-ethyl-phenyl)-propyl]-benzofuran-5-carboxylic acid methyl ester (1.30 g, 3.55 mmol) and 1-bromopinacolone (0.953 g, 5.33 mmol) and K2CO3 (0.98 g, 7.10 mmol) are reacted analogous to Example 1E to give the title compound (1.64 g, 99%).

Sources & evidence

ORD record
ord-876a17270c794296b811ef2d07500b5e
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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