2-Isopropylphenol → HCID 68813591, compound

HRID 2106438Notes

Reaction equation

HRID 2106438 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]([CH2:17][CH3:18])(O)[CH2:14][CH3:15])=[CH:10][C:9]=2[CH:19]=1)=[O:4].[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29])([CH3:22])[CH3:21].B(F)(F)F.CC[O:36][CH2:37][CH3:38]>>[CH3:3][C:5]([CH3:6])([CH3:19])[C:37](=[O:36])[CH2:38][O:29][C:24]1[CH:25]=[CH:26][C:27]([CH:14]([CH:13]([C:11]2[O:12][C:8]3[CH:7]=[CH:6][C:5]([C:3]([OH:2])=[O:4])=[CH:19][C:9]=3[CH:10]=2)[CH2:17][CH3:18])[CH3:15])=[CH:28][C:23]=1[CH:20]([CH3:22])[CH3:21]

Participants

4

Reactant 3

HCID 69432-IsopropylphenolHCID 8000Boron trifluoride etherateHCID 57810594HCID 57810594, compound

Product 1

HCID 68813591HCID 68813591, compoundYield 153.5%

Procedure

2-(1-Ethyl-1-hydroxy-propyl)-benzofuran-5-carboxylic acid methyl ester (0.92 g, 3.507 mmol) and 2-isopropylphenol (0.716 g, 5.26 mmol) and BF3-Et2O (249 mg, 1.753 mmol) are reacted analogous to Example 1D to give the title compound (1.25 g, 94%).

Sources & evidence

ORD record
ord-0db75bd77e2b4a14998ab406f2051688
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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