Potassium Carbonate → HCID 68813539, compound

HRID 2106439Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]([CH2:26][CH3:27])(C3C=CC(O)=C(C(C)C)C=3)[CH2:14][CH3:15])=[CH:10][C:9]=2[CH:28]=1)=[O:4].Br[CH2:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33].[C:37]([O-:40])([O-])=O.[K+].[K+]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([CH:13]([CH:26]([C:6]3[CH:5]=[CH:3][C:37]([O:40][CH2:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[C:8]([CH:9]([CH3:28])[CH3:10])[CH:7]=3)[CH3:27])[CH2:14][CH3:15])=[CH:10][C:9]=2[CH:28]=1)=[O:4]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 21642Bromopinacolone

HCID 57810537HCID 57810537, compound

Product 1

HCID 68813539HCID 68813539, compoundYield 197.5%

Procedure

2-[1-Ethyl-1-(4-hydroxy-3-isopropyl-phenyl)-propyl]-benzofuran-5-carboxylic acid methyl ester (1.25 g, 3.28 mmol) and 1-bromopinacolone (0.882 g, 4.93 mmol) and K2CO3 (0.91 g, 6.57 mmol) are reacted analogous to Example 1E to give the title compound (1.55 g, 99%).

Sources & evidence

ORD record: ord-513e38ecd12947bb85e3ea6fc64db631
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

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