O-Cresol → HCID 57810583, compound

HRID 2106441Notes

Reaction equation

HRID 2106441 reaction equation
[CH2:1]([O:8][C:9]1[CH:23]=[CH:22][C:12]2[CH:13]=[C:14]([C:16](O)([CH2:19][CH3:20])[CH2:17][CH3:18])[O:15][C:11]=2[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:24]1([CH3:31])[C:29]([OH:30])=[CH:28][CH:27]=[CH:26][CH:25]=1.B(F)(F)F.O(CC)CC>>[CH2:1]([O:8][C:9]1[CH:23]=[CH:22][C:12]2[CH:13]=[C:14]([C:16]([C:26]3[CH:27]=[CH:28][C:29]([OH:30])=[C:24]([CH3:31])[CH:25]=3)([CH2:19][CH3:20])[CH2:17][CH3:18])[O:15][C:11]=2[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 335O-CresolHCID 8000Boron trifluoride etherateHCID 57810563HCID 57810563, compound

Product 1

HCID 57810583HCID 57810583, compoundYield 79%

Procedure

3-(6-Benzyloxy-benzofuran-2-yl)-pentan-3-ol (5.40 g, 17.4 mmol) and o-cresol (3.76 g, 34.8 mmol) and BF3—OEt2 (2.47 g, 17.4 mmol) are reacted analogous to Example 1D to give the title compound as a pale yellow oil (5.50 g, 79%).

Sources & evidence

ORD record
ord-5445d2d3ca9248379007c643c017bba8
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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