Potassium Carbonate → HCID 57810559, compound

HRID 2106446Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[C:14]([CH3:15])=[CH:13][C:12]([C:16]([CH2:27][CH3:28])([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([CH3:26])[CH:20]=3)[CH2:17][CH3:18])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2].Br[CH2:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33].C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[C:14]([CH3:15])=[CH:13][C:12]([C:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[C:21]([CH3:26])[CH:20]=3)([CH2:27][CH3:28])[CH2:17][CH3:18])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 21642Bromopinacolone

HCID 57810565HCID 57810565, compound

Product 1

HCID 57810559HCID 57810559, compoundYield 72%

Procedure

5-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-7-methyl-benzofuran-2-carboxylic acid ethyl ester (5.55 g, 14.6 mmol) and 1-bromopinacolone (3.92 g, 21.9 mmol) and K2CO3 (6.04 g, 43.8 mmol) are reacted analogous to Example 1E to give the title compound as a pale yellow oil (5.00 g, 72%).

Sources & evidence

ORD record: ord-36d5a8aa9e48460081ed34c548fc024e
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

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