Potassium Carbonate → HCID 57810572, compound

HRID 2106455Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([CH2:26][CH3:27])([C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH3:25])[CH:19]=3)[CH2:16][CH3:17])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2].Br[CH2:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32].C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32])=[C:20]([CH3:25])[CH:19]=3)([CH2:26][CH3:27])[CH2:16][CH3:17])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 21642Bromopinacolone

HCID 57810579HCID 57810579, compound

Product 1

HCID 57810572HCID 57810572, compoundYield 84.3%

Procedure

5-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-benzofuran-2-carboxylic acid ethyl ester (7.10 g, 19.4 mmol) and 1-bromopinacolone (4.17 g, 23.3 mmol) and K2CO3 (5.35 g, 38.8 mmol) are reacted analogous to Example 1E to give the title compound as a pale yellow oil (7.60 g, 84%).

Sources & evidence

ORD record: ord-c4bbdc9bfaec4a6abc9fbe5b87e78a0d
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

Loading…