Sodium borohydride → HCID 68815574, compound

HRID 2106469Notes

Reaction equation

HRID 2106469 reaction equation
[CH3:1][C:2]([CH3:38])([CH3:37])[C:3](=[O:36])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[O:18][C:19]3[CH:25]=[CH:24][C:23]([C:26]([NH:28][C:29]([CH3:34])([CH3:33])[C:30]([OH:32])=[O:31])=[O:27])=[CH:22][C:20]=3[CH:21]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:35].[BH4-].[Na+]>C1COCC1>[CH2:13]([C:12]([C:17]1[O:18][C:19]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][C:29]([CH3:33])([CH3:34])[C:30]([OH:32])=[O:31])=[O:27])=[CH:22][C:20]=2[CH:21]=1)([C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]([OH:36])[C:2]([CH3:38])([CH3:37])[CH3:1])=[C:7]([CH3:35])[CH:8]=1)[CH2:15][CH3:16])[CH3:14]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 11329875HCID 11329875, compound

Product 1

HCID 68815574HCID 68815574, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-[(2-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-5-carbonyl)-amino]-2-methyl-propionic acid (Example 10) (47 mg, 0.090 mmol) in THF (2.0 mL) are reacted with NaBH4 (7 mg, 0.18 mmol) analogous to Example 8 to yield title compound (45 mg, 96%). MS (ES) m/e: 522.3 (M−1), 524.3 (M+1)

Sources & evidence

ORD record
ord-cef0cdfb65d84ce38f238a5892246902
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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