Sodium borohydride → HCID 57810553, compound

HRID 2106472Notes

Reaction equation

HRID 2106472 reaction equation
[CH3:1][C:2]([CH3:38])([CH3:37])[C:3](=[O:36])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[CH:18]=[C:19]([CH3:34])[C:20]3[O:24][C:23]([C:25]([N:27]([CH2:29][C:30]([OH:32])=[O:31])[CH3:28])=[O:26])=[CH:22][C:21]=3[CH:33]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:35].[BH4-].[Na+]>C1COCC1>[CH2:13]([C:12]([C:17]1[CH:18]=[C:19]([CH3:34])[C:20]2[O:24][C:23]([C:25]([N:27]([CH2:29][C:30]([OH:32])=[O:31])[CH3:28])=[O:26])=[CH:22][C:21]=2[CH:33]=1)([C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]([OH:36])[C:2]([CH3:37])([CH3:38])[CH3:1])=[C:7]([CH3:35])[CH:8]=1)[CH2:15][CH3:16])[CH3:14]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 11156676HCID 11156676, compound

Product 1

HCID 57810553HCID 57810553, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

[(5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-7-methyl-benzofuran-2-carbonyl)-methyl-amino]-acetic acid (310 mg, 0.594 mmol) in THF (2.0 mL) are reacted with NaBH4 (45 mg, 1.19 mmol) analogous to Example 8 to yield title compound (300 mg, 97%). MS (ES) m/e: 522.3 (M−1), 524.3 (M+1)

Sources & evidence

ORD record
ord-9fcdc94b38e44fd0acb9504b4bf34e00
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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