Tetrahydrofuran → HCID 57810585, compound

HRID 2106475Notes

Reaction equation

HRID 2106475 reaction equation
C(O[C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:11][C:9]=2[CH:10]=1)=[O:5])C.[CH3:23][CH2:24][Mg+].[Br-].[CH2:27]1COC[CH2:28]1>>[CH2:16]([O:15][C:12]1[CH:13]=[CH:14][C:8]2[O:7][C:6]([C:4]([OH:5])([CH2:23][CH3:24])[CH2:27][CH3:28])=[CH:10][C:9]=2[CH:11]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 57810562HCID 57810562, compoundHCID 178461630HCID 178461630, compound

Product 1

HCID 57810585HCID 57810585, compoundYield 97%

Procedure

5-Benzyloxy-benzofuran-2-carboxylic acid ethyl ester (6.02 g, 20.3 mmol) and EtMgBr (20.3 mL, 3.0 M) in THF (100 mL) are reacted analogous to Example 18-B to give the title compound (6.10 g, 97%).

Sources & evidence

ORD record
ord-c32e2a947a9147009aa7672a484d9e02
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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