O-Cresol → HCID 57810580, compound

HRID 2106476Notes

Reaction equation

HRID 2106476 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[O:16][C:15]([C:17](O)([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:14][C:13]=2[CH:23]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:24]1([CH3:31])[C:29]([OH:30])=[CH:28][CH:27]=[CH:26][CH:25]=1.B(F)(F)F.O(CC)CC>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[O:16][C:15]([C:17]([C:26]3[CH:27]=[CH:28][C:29]([OH:30])=[C:24]([CH3:31])[CH:25]=3)([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:14][C:13]=2[CH:23]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 335O-CresolHCID 8000Boron trifluoride etherateHCID 57810585HCID 57810585, compound

Product 1

HCID 57810580HCID 57810580, compoundYield 51.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(5-Benzyloxy-benzofuran-2-yl)-pentan-3-ol (6.10 g, 19.7 mmol) and o-cresol (2.55 g, 23.6 mmol) and BF3—OEt2 (1.39 g, 9.83 mmol) in CH2Cl2 are reacted analogous to Example 18-C to give the title compound (4.05 g, 51%).

Sources & evidence

ORD record
ord-7e85d717ada544e2a616edf7f007967d
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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