Potassium Carbonate → HCID 57810587, compound

HRID 2106482Notes

Reaction equation

HRID 2106482 reaction equation
[CH2:1]([C:3]([C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[C:19]([CH3:24])[CH:18]=1)([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:9]=2[CH:10]=1)[CH2:4][CH3:5])[CH3:2].Br[CH2:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:1]([C:3]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[C:19]([CH3:24])[CH:18]=1)([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:9]=2[CH:10]=1)[CH2:4][CH3:5])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 57810569HCID 57810569, compound

Product 1

HCID 57810587HCID 57810587, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-[1-Ethyl-1-(5-hydroxymethyl-benzofuran-2-yl)-propyl]-2-methyl-phenol (653 mg, 2.02 mmol) and 1-bromopinacolone (555 mg, 3.10 mmol) and K2CO3 (570 mg, 4.13 mmol) in acetone (40 mL) are reacted analogous to Example 18-E to give the title compound (870 mg, 100%).

Sources & evidence

ORD record
ord-9ed852a3255b41b69f579802da51bf1e
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

Loading…