反应详情

One hundred g of 1-phenylsemicarbazide was added to 500 ml of trimethyl orthoformate, and about 400 mg of p-toluenesulfonic acid was added to the mixture. It was heated on a steam bath with strong agitation for 2 hours, and was then transferred to a large flask, cooled and evaporated under vacuum. The residue was recrystallized from about 1600 ml of acetic acid to obtain 97 g of the desired intermediate, m.p. 277°-280°.

1. additionwas added to the mixture
2. temperatureIt was heated on a steam bath with strong agitation for 2 hours
3. customwas then transferred to a large flask
4. temperaturecooled
5. customevaporated under vacuum
6. customThe residue was recrystallized from about 1600 ml of acetic acid