Formic Acid → HCID 15016247, compound

HRID 2106569Notes

Reaction equation

HRID 2106569 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][NH:9][C:10]([NH2:12])=[S:11])=[CH:4][CH:3]=1.[CH:13](O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:13]=[N:12][C:10](=[S:11])[NH:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 27636652-(4-Chlorophenyl)hydrazine-1-carbothioamide

Product 1

HCID 15016247HCID 15016247, compound

Procedure

Twelve g of 1-(4-chlorophenyl)thiosemicarbazide was suspended in 60 ml of 95% formic acid, and the mixture was stirred under reflux for 24 hours. The mixture was then cooled, and the product precipitated. It was collected and washed with cold denatured ethanol, and was dried to obtain 6.1 g of the desired intermediate, m.p. 222°-224°.

Workup

  1. temperatureunder reflux for 24 hours
  2. temperatureThe mixture was then cooled
  3. customthe product precipitated
  4. customIt was collected
  5. washwashed
  6. customwas dried

Sources & evidence

ORD record
ord-65c86ade16d14ffd8c61b1d58842ddc7
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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