Potassium Hydroxide → 3-(1-carboxyethoxy)-5-methyl-1-phenyl-1,2,4-1H-triazole

HRID 2106590Notes

Reaction equation

HRID 2106590 reaction equation
C([O:3][C:4]([CH:6]([O:8][C:9]1[N:13]=[C:12]([CH3:14])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[CH3:7])=[O:5])C.[OH-].[K+]>C(O)C>[C:4]([CH:6]([O:8][C:9]1[N:13]=[C:12]([CH3:14])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[CH3:7])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 150162493-(1-ethoxycarbonylethoxy)-5-methyl-1-phenyl-1,2,4-1H-triazole

Product 1

HCID 544347073-(1-carboxyethoxy)-5-methyl-1-phenyl-1,2,4-1H-triazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ten g of the compound of Example 7 was refluxed for 4 hours with 4.1 g of potassium hydroxide in 150 ml of ethanol and the product was collected by extraction with ethyl acetate. The extract was washed with water, dried and evaporated under vacuum, and the residue was recrystallized from toluene to obtain 2.1 g of the desired product, m.p. 157°-159°.

Workup

  1. customthe product was collected by extraction with ethyl acetate
  2. washThe extract was washed with water
  3. customdried
  4. customevaporated under vacuum
  5. customthe residue was recrystallized from toluene

Sources & evidence

ORD record
ord-d4f75632c6ef44ec9f5ef44d75695263
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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