Potassium Hydroxide → 3-(1-carboxyethoxy)-5-methyl-1-phenyl-1,2,4-1H-triazole

Participants

Reaction Steps

Ten g of the compound of Example 7 was refluxed for 4 hours with 4.1 g of potassium hydroxide in 150 ml of ethanol and the product was collected by extraction with ethyl acetate. The extract was washed with water, dried and evaporated under vacuum, and the residue was recrystallized from toluene to obtain 2.1 g of the desired product, m.p. 157°-159°.

Provenance & Evidence