Ethylamine → HCID 15016288, compound

HRID 2106607Notes

Reaction equation

HRID 2106607 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:8]=1)[CH3:5])([OH:3])=O.C(N1C=CN=C1)([N:24]1[CH:28]=[CH:27]N=C1)=O.C(N)C>>[CH2:28]([NH:24][C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:8]=1)[CH3:5])=[O:3])[CH3:27]

Participants

4

Reactant 3

HCID 6341EthylamineHCID 682631,1'-CarbonyldiimidazoleHCID 15016262HCID 15016262, compound

Product 1

HCID 15016288HCID 15016288, compoundYield 39.8%

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 24, 3.4 g of carbonyldiimidazole and 2 ml of 70% aqueous ethylamine. The product was recrystallized from ethanol to obtain 1.3 g of the desired product, m.p. 135°-137°.

Workup

  1. customThe product was recrystallized from ethanol

Sources & evidence

ORD record
ord-f0dd0d739f1d479ca591acc7f08f78be
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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