Thionyl Chloride → HCID 15016245, compound

HRID 2106611Notes

Reaction equation

HRID 2106611 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=1)[CH3:5])(O)=[O:2].S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1>[Cl:20][C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=1)[CH3:5])=[O:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15016244HCID 15016244, compound

Product 1

HCID 15016245HCID 15016245, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 22.8 g portion of the compound of Example 22 was suspended in 150 ml of toluene, and 49 ml of thionyl chloride was added. The mixture was heated under reflux for 2 hours, and was then cooled and evaporated under vacuum. One hundred ml of additional toluene was added and was removed under vacuum, and the residue was recrystallized from toluene.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 2 hours
  3. temperaturewas then cooled
  4. customevaporated under vacuum
  5. additionOne hundred ml of additional toluene was added
  6. customwas removed under vacuum
  7. customthe residue was recrystallized from toluene

Sources & evidence

ORD record
ord-5726c282ed82482b9ffb9b5e4fab87e0
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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