Hydrochloric Acid → 2,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

HRID 2106642Notes

Reaction equation

HRID 2106642 reaction equation
[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1.[ClH:17]>>[ClH:17].[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 863704,5-Dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one

Product 1

HCID 679245022,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

Procedure

21.7 g of 2,3,4,5-tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazine are dissolved, with heating, in 60 ml of 2N hydrochloric acid. The hot solution is filtered and cooled. The precipitate which crystallises out is isolated by filtration, washed with alcohol and ether and dried in vacuo to give the title compound of formula ##STR32## in the form of a colourless crystal powder; m.p. 240-241° C. with decomposition; yield: 19 g (75%).

Workup

  1. filtrationThe hot solution is filtered
  2. temperaturecooled
  3. customThe precipitate which crystallises out
  4. customis isolated by filtration
  5. washwashed with alcohol and ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-10518bb3c4774c4e8e131818f65ec661
Source dataset
uspto-grants-1990_06
Patent number
US04931439

Reaction notes

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