HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → (Piperidin-4-yl)methanol--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | (1-Benzylpiperidin-4-YL)methanol hydrochloride | HCID 23048929 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (Piperidin-4-yl)methanol--hydrogen chloride (1/1) | HCID 24191744 | 89.1% |
Reaction Steps
105 g of 1-benzyl-4-piperidinemethanol hydrochloride, 2 l of ethanol and 12.5 g of palladinized charcoal are introduced into a Parr bottle, and a hydrogenolysis is performed at 50° C. under a pressure of 0.4 MPa. The mixture is filtered and the filtrate evaporated off under reduced pressure. 58.7 g of solid are obtained. Melting point: 128°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931449 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-79cc2909bb1e424c8c898567924181d3 |
| Source note | uspto-grants-1990_06 |