Methane → (Piperidin-4-yl)methanol--hydrogen chloride (1/1)

HRID 2106647Notes

Reaction equation

HRID 2106647 reaction equation
[ClH:1].C([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[CH2:11][CH2:10]1)C1C=CC=CC=1.C>C(O)C>[ClH:1].[NH:9]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 297MethaneHCID 23048929(1-Benzylpiperidin-4-YL)methanol hydrochloride

Product 1

HCID 24191744(Piperidin-4-yl)methanol--hydrogen chloride (1/1)Yield 89.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

105 g of 1-benzyl-4-piperidinemethanol hydrochloride, 2 l of ethanol and 12.5 g of palladinized charcoal are introduced into a Parr bottle, and a hydrogenolysis is performed at 50° C. under a pressure of 0.4 MPa. The mixture is filtered and the filtrate evaporated off under reduced pressure. 58.7 g of solid are obtained. Melting point: 128°-130° C.

Workup

  1. customis performed at 50° C. under a pressure of 0.4 MPa
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated off under reduced pressure

Sources & evidence

ORD record
ord-79cc2909bb1e424c8c898567924181d3
Source dataset
uspto-grants-1990_06
Patent number
US04931449

Reaction notes

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