HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6,11-Dihydro-11-[[3-[2-(hexahydro-1H-1-azepinyl)ethyl]-1-piperidinyl]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | HCID 14209983 | — |
| Reactant | 3-[2-(hexahydro-1H-1-azepinyl)ethyl]piperidine | HCID 15057314 | — |
| Solvent | Dichloromethane cyclohexane methanol | HCID 69163855 | — |
| Product | 6,11-Dihydro-11-[[3-[2-(hexahydro-1H-1-azepinyl)ethyl]-1-piperidinyl]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | HCID 14369667 | 58% |
Reaction Steps
Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 3-[2-(hexahydro-1H-1-azepinyl)ethyl]piperidine in a yield of 58% of theory. Colourless crystals, m.p. 152°-154° C. (acetonitrile), Rf 0.64 (Macherey-Nagel, Polygram® SIL G/UV254, pre-coated plastic sheets for TLC; eluant: dichloromethane/cyclohexane/methanol/conc. ammonia 68/15/15/2, v/v/v/v)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-d3189089362b4da99cde080702352054 |
| Source note | uspto-grants-1990_06 |