11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one → HCID 14369668, compound

HRID 2106698Notes

Reaction equation

HRID 2106698 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[N:20]1([CH2:25][CH2:26][CH2:27][CH2:28][CH:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH2:24][CH2:23][CH2:22][CH2:21]1>C(O)C>[N:20]1([CH2:25][CH2:26][CH2:27][CH2:28][CH:29]2[CH2:34][CH2:33][N:32]([C:2]([N:4]3[C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=4[NH:8][C:7](=[O:15])[C:6]4[CH:16]=[CH:17][CH:18]=[N:19][C:5]3=4)=[O:3])[CH2:31][CH2:30]2)[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 1420998311-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 15057323HCID 15057323, compound

Product 1

HCID 14369668HCID 14369668, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 4-[4-(1-pyrrolidinyl)butyl]piperidine in a yield of 72% of theory. Colourless crystals, m.p. 193°-195° C. (ethanol).

Sources & evidence

ORD record
ord-978ac69415d245788ff3ddcd4e059ae4
Source dataset
uspto-grants-1990_06
Patent number
US04931436

Reaction notes

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