11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one → HCID 23048726, compound

HRID 2106709Notes

Reaction equation

HRID 2106709 reaction equation
[Cl:1][C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH2:20]([N:22]([CH2:36][CH3:37])[CH2:23][CH2:24][CH2:25][N:26]([CH3:35])[CH2:27][CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][NH:30]1)[CH3:21].O.[ClH:39].Cl>>[OH2:3].[ClH:1].[ClH:39].[CH2:36]([N:22]([CH2:20][CH3:21])[CH2:23][CH2:24][CH2:25][N:26]([CH3:35])[CH2:27][CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][N:30]1[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3])[CH3:37]

Participants

4

Reactant 3

HCID 1420998311-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 15057320HCID 15057320, compoundHCID 21226127Hydrate;dihydrochloride

Product 1

HCID 23048726HCID 23048726, compoundYield 48%

Procedure

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 2-[2-[[3-(diethylamino)propyl]methylamino]ethyl]piperidine in a yield of 48% of theory. The colourless dihydrochloride-hydrate melted at 145°-150° C. (D.).

Sources & evidence

ORD record
ord-57d338983ff74752a9ce1305da7eb3f4
Source dataset
uspto-grants-1990_06
Patent number
US04931436

Reaction notes

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