Ammonia → HCID 15057332, compound

HRID 2106711Notes

Reaction equation

HRID 2106711 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][CH:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH2:23][CH2:22]1.N>C(OCC)(=O)C.CO.C1CCCCC1>[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][CH:30]2[CH2:31][CH2:32][N:33]([C:2]([N:4]3[C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=4[C:8](=[O:15])[NH:7][C:6]4[CH:16]=[CH:17][CH:18]=[N:19][C:5]3=4)=[O:3])[CH2:34][CH2:35]2)[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 15057324HCID 15057324, compound

Product 1

HCID 15057332HCID 15057332, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 22064753Cyclohexane ethyl acetate methanolSolvent

Procedure

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-[3-(4-methyl-1-piperazinyl)propyl]piperidine in a yield of 17% of theory. Colourless crystals, m.p. 213°-214° C.; Rf 0.25 (Merck DC ready-made TLC plates, silica gel 60 F254 ; eluant: ethyl acetate/methanol/cyclohexane/conc. ammonia 80/10/10/1 v/v/v/v).

Sources & evidence

ORD record
ord-dbb86a5ce9a647688e4691c5a201990d
Source dataset
uspto-grants-1990_06
Patent number
US04931436

Reaction notes

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