HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 15057332, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | HCID 15057324 | HCID 15057324 | — |
| Solvent | Cyclohexane ethyl acetate methanol | HCID 22064753 | — |
| Product | HCID 15057332 | HCID 15057332 | 17% |
Reaction Steps
Prepared analogously to Example 4 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-[3-(4-methyl-1-piperazinyl)propyl]piperidine in a yield of 17% of theory. Colourless crystals, m.p. 213°-214° C.; Rf 0.25 (Merck DC ready-made TLC plates, silica gel 60 F254 ; eluant: ethyl acetate/methanol/cyclohexane/conc. ammonia 80/10/10/1 v/v/v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-dbb86a5ce9a647688e4691c5a201990d |
| Source note | uspto-grants-1990_06 |