Water → HCID 15068891, compound

HRID 2106730Notes

Reaction equation

HRID 2106730 reaction equation
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[OH:11].C([O-])([O-])=O.[Na+].[Na+].F[C:19]1[CH:20]=[N+:21]([O-:28])[CH:22]=[CH:23][C:24]=1[N+:25]([O-:27])=[O:26].O>CN(C=O)C>[N+:25]([C:24]1[CH:23]=[CH:22][N+:21]([O-:28])=[CH:20][C:19]=1[O:11][C:2]1[CH:3]=[CH:4][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:1]=1)([O-:27])=[O:26]

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 143055,6,7,8-Tetrahydro-2-naphtholHCID 5940283-Fluoro-4-nitropyridin-1-ium-1-olate

Product 1

HCID 15068891HCID 15068891, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To a solution of 5,6,7,8-tetrahydro-2-naphthol in 50 ml of DMF was added Na2CO3 (10 g) portionwise and this mixture was stirred for 15 minutes at room temperature. A solution of 3-fluoro-4-nitropyridine-N-oxide in 50 ml DMF was added dropwise and the reaction was allowed to proceed for four hours at room temperature. The mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and dried (sat NaCl, anhy MgSO4).

Workup

  1. waitto proceed for four hours at room temperature
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried (sat NaCl, anhy MgSO4)

Sources & evidence

ORD record
ord-ffe0237361e34624b002d1dd03fdd217
Source dataset
uspto-grants-1990_06
Patent number
US04931457

Reaction notes

Loading…