N,N-Dimethylethylenediamine → HCID 10340404, compound

HRID 2106818Notes

Reaction equation

HRID 2106818 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:13]=[N:12][C:11]=2[C:22]([O:24]CC)=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:27][N:28]([CH3:32])[CH2:29][CH2:30][NH2:31]>>[CH3:27][N:28]([CH3:32])[CH2:29][CH2:30][NH:31][C:22]([C:11]1[N:12]=[N:13][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:15][C:10]=1[C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:24]

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 10020712HCID 10020712, compound

Product 1

HCID 10340404HCID 10340404, compoundYield 92.8%

Conditions

Temperature
90 °C

Procedure

A mixture of ethyl 4-(3-nitrophenyl)-6-phenyl-3-pyridazinecarboxylate (1.0 g) and 2-dimethylaminoethylamine (0.75 g) was heated for 30 minutes at 90° C. with stirring. After allowing to cool at ambient temperature, the resulting precipitates were collected by filtration, recrystallized from diethyl ether to give 3-(2-dimethylaminoethylcarbamoyl)-4-(3-nitrophenyl)-6-phenylpyridazine (1.04 g).

Workup

  1. temperatureto cool at ambient temperature
  2. customthe resulting precipitates
  3. filtrationwere collected by filtration
  4. customrecrystallized from diethyl ether

Sources & evidence

ORD record
ord-8163c569de7744c5aeedb2d2b38da26c
Source dataset
uspto-grants-1990_06
Patent number
US04931453

Reaction notes

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