反应详情

(M)(a) 15.4 g of a diastereomer mixture of 2-hexyl-3-hydroxy-(R)-5-[(tetrahydro-2H-pyran-2-yl)oxy]hexadecanoic acid were dissolved in 160 ml of ethanol and 800 mg of toluene-4-sulfonic acid monohydrate were added. The reaction mixture was heated to 55°-60° C. until the reaction was finished. The solvent was removed in vacuo and the residue was dissolved in 160 ml of dichloromethane. The solution was stirred at room temperature for 1 hour. The reaction mixture was evaporated. The material obtained was chromatographed on silica gel. There was obtained tetrahydro-3-hexyl-4-hydroxy-(R)-6-undecyl-2H-pyran-2-one, m.p. 95°-96° C.

1. temperatureThe reaction mixture was heated to 55°-60° C. until the reaction
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in 160 ml of dichloromethane
4. customThe reaction mixture was evaporated
5. customThe material obtained
6. customwas chromatographed on silica gel