反应详情

40 g of 3-methoxy-4-methylthiophene were dissolved in 120 cm3 of toluene together with 120 g of 1-dodecanol, and the solution was refluxed with 2 g of NaHSO4. 19 ml of a methanol/toluene mixture were separated off over a period of 3 hours. The solution was washed with water until neutral, dried over MgSO4 and subsequently fractionated. At 141° to 143° C. and 0.013 mbar, 55.6 g of 3-dodecyloxy-4-methylthiophene distilled over. 97% pure by GC, which corresponds to 63% of the theoretical yield. The substance was characterized by mass spectrum and 1H-NMR.

1. custom19 ml of a methanol/toluene mixture were separated off over a period of 3 hours
2. washThe solution was washed with water until neutral,
3. dry with materialdried over MgSO4
4. distillationAt 141° to 143° C. and 0.013 mbar, 55.6 g of 3-dodecyloxy-4-methylthiophene distilled over