Methanol → Methyl 2-chloro-3-nitrobenzoate

HRID 2106941Notes

Reaction equation

HRID 2106941 reaction equation
[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:19]O>>[CH3:19][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]=1[Cl:1]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 198702-Chloro-3-nitrobenzoic acid

Product 1

HCID 10751184Methyl 2-chloro-3-nitrobenzoate

Procedure

50.0 g (0.248 mol) of 2-chloro-3-nitrobenzoic acid are dissolved in 500 ml of methanol, and 20 ml of concentrated sulfuric acid are added thereto. After refluxing for 24 hours, the mixture is poured onto ice/water and the white precipitate is isolated by filtration, washed with water and dried.

Workup

  1. temperatureAfter refluxing for 24 hours
  2. additionthe mixture is poured onto ice/water
  3. customthe white precipitate is isolated by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-9cae64afbcf243898d60db43c73538cd
Source dataset
uspto-grants-1990_06
Patent number
US04931581

Reaction notes

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