Methanol → HCID 43449021, compound

HRID 2106943Notes

Reaction equation

HRID 2106943 reaction equation
S(=O)(=O)(O)O.[Br:6][C:7]1[CH:8]=[C:9]([N+:17]([O-:19])=[O:18])[C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13].[CH3:20]O>>[CH3:20][O:13][C:12](=[O:14])[C:11]1[CH:15]=[C:7]([Br:6])[CH:8]=[C:9]([N+:17]([O-:19])=[O:18])[C:10]=1[Cl:16]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 22403367HCID 22403367, compound

Product 1

HCID 43449021HCID 43449021, compound

Procedure

20 ml of concentrated sulfuric acid are added dropwise to 51.0 g (0.182 mol) of 5-bromo-2-chloro-3-nitrobenzoic acid and 500 ml of methanol. The mixture is then boiled under reflux for 16 hours and subsequently cooled with an ice bath and the resulting precipitate is isolated by filtration. The mother liquor is concentrated, water is added and the resulting precipitate is isolated by filtration.

Workup

  1. temperatureunder reflux for 16 hours
  2. temperaturesubsequently cooled with an ice bath
  3. customthe resulting precipitate is isolated by filtration
  4. concentrationThe mother liquor is concentrated
  5. additionwater is added
  6. customthe resulting precipitate is isolated by filtration

Sources & evidence

ORD record
ord-ffc5eaa6366d4978ad52247d75d0048f
Source dataset
uspto-grants-1990_06
Patent number
US04931581

Reaction notes

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