HCID 14350368, compound → 4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole

HRID 2106997Notes

Reaction equation

HRID 2106997 reaction equation
Cl.[Cl:2][CH2:3][C:4](=O)[CH2:5][S:6][C:7](=[NH:15])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1>S(=O)(=O)(O)O>[Cl:2][CH2:3][C:4]1[N:15]=[C:7]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[S:6][CH:5]=1

Participants

3

Reactant 1

HCID 14350368HCID 14350368, compound2×

Product 1

HCID 6102974-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

11.95 g (40 mmol) of the 4-chlorothiobenzimidic acid-3-chloroacetonyl ester hydrochloride obtained in (b) were introduced into 40 ml concentrated sulphuric acid at room temperature, with stirring, left to stand at room temperature for 30 minutes and then poured onto ice. The crystallate was drawn off, washed free of acid with water, and dried.

Workup

  1. waitleft
  2. additionpoured onto ice
  3. washwashed free of acid with water
  4. customdried

Sources & evidence

ORD record
ord-2459c0ed9b544f75a30364a9d7697235
Source dataset
uspto-grants-1990_06
Patent number
US04933328

Reaction notes

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