HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2107035Generated: October 31, 2026
Hydrochloric Acid → 5-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one
https://huagongshe.com/reaction/2107035
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 3,3-Dimethyl-1,3-dihydro-indol-2-one | HCID 313100 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one | HCID 10752379 | — |
Reaction Steps
13.3 g aluminium chloride and 2.2 ml DMF were mixed and heated with stirring, at 70° C. during 15 min. After cooling to 40° C., 1.5 g 1,3-dihydro-3,3-dimethyl-2H-indol-2-one and 1.1 g 2-chloroacetyl chloride were added and stirred at 70° C. for 45 min. The mixture was poured onto 50 g ice and 10 ml 10N HCl and extracted with 3×75 ml ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04933336 |
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| Source dataset | uspto-grants-1990_06 |
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| ORD ID | ord-264fb957ab7b49d5846a9d96469283e1 |
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| Source note | uspto-grants-1990_06 |
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