反应详情

温度

70 °C

13.3 g aluminium chloride and 2.2 ml DMF were mixed and heated with stirring, at 70° C. during 15 min. After cooling to 40° C., 1.5 g 1,3-dihydro-3,3-dimethyl-2H-indol-2-one and 1.1 g 2-chloroacetyl chloride were added and stirred at 70° C. for 45 min. The mixture was poured onto 50 g ice and 10 ml 10N HCl and extracted with 3×75 ml ethyl acetate.

1. temperatureheated
2. temperatureAfter cooling to 40° C.
3. stirringstirred at 70° C. for 45 min
4. extractionextracted with 3×75 ml ethyl acetate