5-(2-Chloroacetyl)-1,3-dihydro-3-methyl-2H-indol-2-one → HCID 15111515, compound

HRID 2107037Notes

Reaction equation

HRID 2107037 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH:8]2[CH3:15])=O.[C:16]([O:20]C)(=[S:19])[NH:17][NH2:18]>C(#N)C>[O:20]=[C:16]1[NH:17][N:18]=[C:3]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH:8]3[CH3:15])[CH2:2][S:19]1

Participants

4

Reactant 2

HCID 49627245-(2-Chloroacetyl)-1,3-dihydro-3-methyl-2H-indol-2-oneHCID 10171237O-methyl hydrazinecarbothioate

Product 1

HCID 15111515HCID 15111515, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.0 g 5-(2-chloroacetyl)-1,3-dihydro-3-methyl-2H-indol-2-one, 0.37 g O-methyl thiocarbazate, and 20 ml acetonitrile were refluxed for 2 hrs. The precipitate was isolated by filtration and washed with hot acetonitrile to yield a yellowish powder, 450 mg.

Workup

  1. customThe precipitate was isolated by filtration
  2. washwashed with hot acetonitrile
  3. customto yield a yellowish powder, 450 mg

Sources & evidence

ORD record
ord-3e043bc9bf1745018843c558e1c8407d
Source dataset
uspto-grants-1990_06
Patent number
US04933336

Reaction notes

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