Hydroxyamine hydrochloride → HCID 136364614, compound

HRID 2107051Notes

Reaction equation

HRID 2107051 reaction equation
[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:10]=1[C:11]1[C:12]([CH2:34][O:35][CH3:36])=[C:13]([CH:32]=O)[N:14]=[CH:15][C:16]=1[N:17]2[S:22]([C:25]1[CH:31]=[CH:30][C:28]([CH3:29])=[CH:27][CH:26]=1)(=[O:24])=[O:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:38][OH:39]>C(O)C>[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:10]=1[C:11]1[C:12]([CH2:34][O:35][CH3:36])=[C:13]([CH:32]=[N:38][OH:39])[N:14]=[CH:15][C:16]=1[N:17]2[S:22]([C:25]1[CH:31]=[CH:30][C:28]([CH3:29])=[CH:27][CH:26]=1)(=[O:23])=[O:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 13799191HCID 13799191, compound

Product 1

HCID 136364614HCID 136364614, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

500 mg of 5-benzyloxy-4-methoxymethyl-9-tosyl-β-carboline-3-carbaldehyde is heated in 15 ml of ethanol to 70° C., combined with 84 mg of hydroxylamine hydrochloride in 10 ml of ethanol and heated for 1.5 hours to 70° C. Then the mixture is concentrated to 5 ml, poured on 40 ml of water, and suctioned off. The residue (450 mg) is utilized after drying in the subsequent stage without further purification.

Workup

  1. temperatureheated for 1.5 hours to 70° C
  2. concentrationThen the mixture is concentrated to 5 ml
  3. additionpoured on 40 ml of water
  4. customafter drying in the subsequent stage without further purification

Sources & evidence

ORD record
ord-da1d26ca6cdc40d3ad3dd1e17bd68ac6
Source dataset
uspto-grants-1990_06
Patent number
US04933345

Reaction notes

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