反应详情

To a suspension of potassium carbonate (8.14 g) and 1,2,4-triazole (8.14 g) in acetonitrile (100 ml) was added 1-(4-chlorophenyl)-2,3-epoxypropane (9.0 g), and the resulting suspension was heated to 70° for 4.5 h. The excess acetonitrile was evaporated under reduced pressure, and the residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with water and dried, and the solvent was evaporated to give a colourless oil. Purification by column chromatography on silica, eluting with chloroform/methanol, 95:5 by volume, gave 1-(4-chlorophenyl)-3-(1,2,4-triazol-1-yl)-2-propanol as a colourless oil which crystallised on standing, m.p. 104°-6°.

1. temperaturethe resulting suspension was heated to 70° for 4.5 h
2. customThe excess acetonitrile was evaporated under reduced pressure
3. customthe residue was partitioned between ethyl acetate and water
4. customThe organic layer was separated
5. washwashed with water
6. customdried
7. customthe solvent was evaporated
8. customto give a colourless oil
9. customPurification by column chromatography on silica
10. washeluting with chloroform/methanol, 95:5 by volume