3-Thiazolidineacetic acid, 4-oxo-2-thioxo- → HCID 53748478, compound

HRID 2107155Notes

Reaction equation

HRID 2107155 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=O)[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[S:14]1[CH2:20][C:18](=[O:19])[N:17]([CH2:21][C:22]([OH:24])=[O:23])[C:15]1=[S:16].[C:25]([O-])(=[O:27])[CH3:26].[Na+]>C(O)(=O)C>[C:25]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[C:20]2[S:14][C:15](=[S:16])[N:17]([CH2:21][C:22]([OH:24])=[O:23])[C:18]2=[O:19])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 517045Sodium AcetateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 53748478HCID 53748478, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture comprising 4.35 g of ethyl 2-aminothiazol-4-ylglyoxylate, 5 g of rhodanine-3-acetic acid, 2.7 g of sodium acetate and 50 ml of acetic acid was heated under reflux for 2 days. The reaction mixture was then worked up as in Example 1, to give the desired compound as a yellow powder.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 days

Sources & evidence

ORD record
ord-6939ba4eb0594c359f88d98f8e939b5e
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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