Ammonia → 5-{1-Ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine acetic acid

HRID 2107159Notes

Reaction equation

HRID 2107159 reaction equation
[C:1]1([NH:7][C:8](=[O:22])[NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15](=O)[C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:23]1[CH2:29][C:27](=[O:28])[NH:26][C:24]1=[S:25].[Cl-].[NH4+].N>C(O)C>[CH2:19]([O:18][C:16]([C:15](=[C:29]1[S:23][C:24](=[S:25])[N:26]([CH2:15][C:16]([OH:18])=[O:17])[C:27]1=[O:28])[C:13]1[N:14]=[C:10]([NH:9][C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:22])[S:11][CH:12]=1)=[O:17])[CH3:20]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 1201546RhodanineHCID 15053489Ethyl 2-(3-phenylureido)thiazol-4-ylglyoxylate

Product 1

HCID 541363965-{1-Ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Example 1, the desired compound was prepared from 3 g of ethyl 2-(3-phenylureido)thiazol-4-ylglyoxylate, 1.25 g of rhodanine, 1 g of ammonium chloride 1 ml of 28% v/v aqueous ammonia and 10 ml of ethanol. The resulting product was a yellow powder having the following physical properties.

Sources & evidence

ORD record
ord-21a70c9232dd45a8ba84d52482b134e2
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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