Hydrochloric Acid → 5-(2-Aminothiazol-4-ylmethylene)rhodanine-3-acetic acid

HRID 2107169Notes

Reaction equation

HRID 2107169 reaction equation
C([NH:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=[C:27]2[S:31][C:30](=[S:32])[N:29]([CH2:33][C:34]([O-:36])=[O:35])[C:28]2=[O:37])[N:25]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[NH2+]1CCCCC1.Cl>O1CCOCC1>[NH2:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=[C:27]2[S:31][C:30](=[S:32])[N:29]([CH2:33][C:34]([OH:36])=[O:35])[C:28]2=[O:37])[N:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 74015737Piperidinium 5-(2-Tritylaminothiazol-4-ylmethylene)rhodanine-3-acetate

Product 1

HCID 542543345-(2-Aminothiazol-4-ylmethylene)rhodanine-3-acetic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture comprising 2.2 g of piperidinium 5-(2-tritylaminothiazol-4-ylmethylene)rhodanine-3-acetate and 30 ml of a 4N dioxane solution of hydrogen chloride was stirred at room temperature for 30 minutes, and the resulting mixture was left to stand overnight. The crystalline product which precipitated out was collected by filtration and washed with dioxane, giving the desired compound as a brownish-orange powder.

Workup

  1. waitthe resulting mixture was left
  2. waitto stand overnight
  3. customThe crystalline product which precipitated out
  4. filtrationwas collected by filtration
  5. washwashed with dioxane

Sources & evidence

ORD record
ord-d46df324df1744008fae680960261a9a
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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