HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → Isopropyl 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine-3-acetate sesquihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-{1-Ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine acetic acid | HCID 54136396 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | Isopropyl 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine-3-acetate sesquihydrate | HCID 131716427 | — |
Reaction Steps
Following a procedure similar to that described in Example 27, the desired compound was prepared from 1 g of 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine-3-acetic acid, 0.5 g of isopropyl bromide, 0.25 g of triethylamine and 10 ml of hexamethylphosphoric triamide. The resulting yellow crystalline product had the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04933355 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-78c15ff8f028446296bb6eb3e7a1d3c6 |
| Source note | uspto-grants-1990_06 |