HRID2107177

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6358

2-Bromopropane

C3H7Br

HCID8471

Triethylamine

C6H15N

结构：CCOC(=O)C(=C1SC(=S)N(CC(=O)O)C1=O)c1csc(NC(=O)Nc2ccccc2)n1

HCID54136396

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(=C1SC(=S)N(CC(=O)OC(C)C)C1=O)c1csc(NC(=O)Nc2ccccc2)n1.CCOC(=O)C(=C1SC(=S)N(CC(=O)OC(C)C)C1=O)c1csc(NC(=O)Nc2ccccc2)n1.O.O.O

HCID131716427

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID12679

Hexamethylphosphoramide

C6H18N3OP

PROCEDURE

实验过程

Following a procedure similar to that described in Example 27, the desired compound was prepared from 1 g of 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine-3-acetic acid, 0.5 g of isopropyl bromide, 0.25 g of triethylamine and 10 ml of hexamethylphosphoric triamide. The resulting yellow crystalline product had the following physical properties.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-78c15ff8f028446296bb6eb3e7a1d3c6
来源数据集: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04933355
来源说明: uspto-grants-1990_06

反应 SMILES

[CH2:1]([O:3][C:4]([C:6](=[C:22]1[S:26][C:25](=[S:27])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:23]1=[O:32])[C:7]1[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])[S:10][CH:11]=1)=[O:5])[CH3:2].[CH:33](Br)([CH3:35])[CH3:34].C(N(CC)CC)C>CN(C)P(=O)(N(C)C)N(C)C>[OH2:3].[CH2:1]([O:3][C:4]([C:6](=[C:22]1[S:26][C:25](=[S:27])[N:24]([CH2:28][C:29]([O:31][CH:33]([CH3:35])[CH3:34])=[O:30])[C:23]1=[O:32])[C:7]1[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:14])[S:10][CH:11]=1)=[O:5])[CH3:2].[OH2:3].[OH2:3].[CH:33]([O:30][C:29](=[O:31])[CH2:28][N:24]1[C:23](=[O:32])[C:22](=[C:6]([C:7]2[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[O:14])[S:10][CH:11]=2)[C:4]([O:3][CH2:1][CH3:2])=[O:5])[S:26][C:25]1=[S:27])([CH3:35])[CH3:34]