Ammonia → 5-[2-(3-Phenylureido)thiazol-4-ylmethylene]thiazolidine-2,4-dione

HRID 2107193Notes

Reaction equation

HRID 2107193 reaction equation
[C:1]1([NH:7][C:8](=[O:17])[NH:9][C:10]2[S:11][CH:12]=[C:13]([CH:15]=O)[N:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:18]1[CH2:22][C:21](=[O:23])[NH:20][C:19]1=[O:24].[Cl-].[NH4+].N>C(O)C>[C:1]1([NH:7][C:8](=[O:17])[NH:9][C:10]2[S:11][CH:12]=[C:13]([CH:15]=[C:22]3[S:18][C:19](=[O:24])[NH:20][C:21]3=[O:23])[N:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 5437ThiazolidinedioneHCID 25517Ammonium ChlorideHCID 150535142-(3-Phenylureido)thiazole-4-carbaldehyde

Product 1

HCID 536829585-[2-(3-Phenylureido)thiazol-4-ylmethylene]thiazolidine-2,4-dione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Example 1, the desired compound was prepared from 1.1 g of 2-(3-phenylureido)thiazole-4-carbaldehyde, 0.52 g of 2,4-thiazolidinedione, 0.6 g of ammonium chloride, 0.6 ml of 28% v/v aqueous ammonia and 20 ml of ethanol. The resulting product was a yellow powder having the following physical properties.

Sources & evidence

ORD record
ord-4590afc7eebd4b96b64f66fe402339d6
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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