Ammonia → 5-(2-Diphenylmethylaminothiazol-4-ylmethylene)rhodanine--acetic acid

HRID 2107204Notes

Reaction equation

HRID 2107204 reaction equation
[C:1]1([CH:7]([NH:14][C:15]2[S:16][CH:17]=[C:18]([CH:20]=O)[N:19]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:22]1[CH2:28][C:26](=[O:27])[N:25]([CH2:29][C:30]([OH:32])=[O:31])[C:23]1=[S:24].[Cl-].[NH4+].N>C(O)C>[C:8]1([CH:7]([NH:14][C:15]2[S:16][CH:17]=[C:18]([CH:20]=[C:28]3[S:22][C:23](=[S:24])[N:25]([CH2:29][C:30]([OH:32])=[O:31])[C:26]3=[O:27])[N:19]=2)[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 230476352-Diphenylmethylaminothiazole-4-carbaldehyde

Product 1

HCID 545717655-(2-Diphenylmethylaminothiazol-4-ylmethylene)rhodanine--acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Example 1, the desired compound was prepared from 1.95 g of 2-diphenylmethylaminothiazole-4-carbaldehyde. 1.32 g of rhodanine-3-acetic acid, 0.4 g of ammonium chloride, 0.4 ml of 28% v/v aqueous ammonia and 20 ml of ethanol. The resulting product was a reddish-brown powder having the following physical properties.

Sources & evidence

ORD record
ord-32d7fa8a3a684f44be86cf99725fada2
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

Loading…