3-Methoxyphenyl isocyanate → HCID 15053491, compound

HRID 2107224Notes

Reaction equation

HRID 2107224 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([N:22]=[C:23]=[O:24])[CH:19]=[CH:20][CH:21]=1>CN(C)C=O>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([NH:22][C:23](=[O:24])[NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 878433-Methoxyphenyl isocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053491HCID 15053491, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 5 g of ethyl 2-aminothiazol-4-ylglyoxylate, 4.5 g of m-methoxyphenyl isocyanate and 40 ml of dimethylformamide, as yellow crystals having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-061722c3406d4356ae1aec6d4354c1fe
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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