2,4-Difluorophenyl isocyanate → HCID 15053501, compound

HRID 2107242Notes

Reaction equation

HRID 2107242 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[N:22]=[C:23]=[O:24]>CN(C)C=O>[F:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[NH:22][C:23](=[O:24])[NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 5932582,4-Difluorophenyl isocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053501HCID 15053501, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 5 g of ethyl 2-aminothiazol-4-ylglyoxylate, 5.8 g of 2,4-difluorophenyl isocyanate and 30 ml of dimethylformamide. The resulting product was a white powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-3b223ae776764812856e300f22facc58
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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