4-Fluoro-3-nitrophenyl isocyanate → HCID 15053502, compound

HRID 2107243Notes

Reaction equation

HRID 2107243 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]=[O:23])=[CH:17][C:16]=1[N+:24]([O-:26])=[O:25]>CN(C)C=O>[F:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:23])[NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)=[CH:17][C:16]=1[N+:24]([O-:26])=[O:25]

Participants

4

Reactant 2

HCID 1441174-Fluoro-3-nitrophenyl isocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053502HCID 15053502, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 5 g of ethyl 2-aminothiazol-4-ylglyoxylate. 5.5 g of 4-fluoro-3-nitrophenyl isocyanate and 30 ml of dimethylformamide. The resulting product was a yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-260f6b3188a34eddbcc15b6e3c87684e
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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